Libros
Jose Russo · Springer, 2014
This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place.
The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome.
The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
Universitario · En inglés
Bryan Turner
John Wiley & Sons, Ltd., 2007
Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control…
Introducción · En inglés
Martin H. Johnson
Blackwell Publishing Limited, 2007
First Prize in the Obstetrics and Gynaecology category at the British Medical Association Book Awards 2008 Essential Reproduction provides an integrated and multidisciplinary approach to the study of reproduction for students taking courses in reproductive physiology in a wide range of subjects, from medicine and…
Divulgación · En inglés
Nicholas Wade
Simon & Schuster, 2002
With the decoding of the human genome, researchers can now read the genetic program that evolution has written for the human body. A new generation of medical treatments is at hand, and researchers hope to uncover the genetic roots of illness and develop new therapies for most major diseases. Here, New York Times…
Universitario · En inglés
Catherine Rice-Evans, R. H. Burdon
Elsevier Publishing Company, 2004
Universitario · En inglés
Valerie W. Hu
Springer, 1994
Regulators of the Cell Cycle: Protein Phosphorylation and the Regulation of Key Events in Oocyte and Egg Cell Cycles; J.L. Maller. Control of Cell Proliferation: Extracellular Signal-Regulated Protein Kinases 1,2, and 3; D.J. Robbins, et al. Cell Cycle Control of Gene Expression and Repair: Histone Gene Transcription…
Divulgación · En inglés
David Reich
Pantheon Books, 2018
A groundbreaking book about how ancient DNA has profoundly changed our understanding of human history. Geneticists like David Reich have made astounding advances in the field of genomics, which is proving to be as important as archeology, linguistics, and written records as a means to understand our ancestry. In Who…
